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Macrophage barrier in the tumor microenvironment and potential clinical applications.

Authors :
Ji, Shuai
Shi, Yuqing
Yin, Bo
Source :
Cell Communication & Signaling; 1/26/2024, Vol. 22 Issue 1, p1-14, 14p
Publication Year :
2024

Abstract

The tumor microenvironment (TME) constitutes a complex microenvironment comprising a diverse array of immune cells and stromal components. Within this intricate context, tumor-associated macrophages (TAMs) exhibit notable spatial heterogeneity. This heterogeneity contributes to various facets of tumor behavior, including immune response modulation, angiogenesis, tissue remodeling, and metastatic potential. This review summarizes the spatial distribution of macrophages in both the physiological environment and the TME. Moreover, this paper explores the intricate interactions between TAMs and diverse immune cell populations (T cells, dendritic cells, neutrophils, natural killer cells, and other immune cells) within the TME. These bidirectional exchanges form a complex network of immune interactions that influence tumor immune surveillance and evasion strategies. Investigating TAM heterogeneity and its intricate interactions with different immune cell populations offers potential avenues for therapeutic interventions. Additionally, this paper discusses therapeutic strategies targeting macrophages, aiming to uncover novel approaches for immunotherapy. EjPgUqH7NocL1u9xj7Aojm Video Abstract [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1478811X
Volume :
22
Issue :
1
Database :
Complementary Index
Journal :
Cell Communication & Signaling
Publication Type :
Academic Journal
Accession number :
175022256
Full Text :
https://doi.org/10.1186/s12964-023-01424-6