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Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health.
- Source :
- Chinese Journal of Integrative Medicine; Feb2024, Vol. 30 Issue 2, p171-180, 10p
- Publication Year :
- 2024
-
Abstract
- The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity, type 2 diabetes mellitus, heart failure, and non-alcoholic fatty liver disease. Polysaccharides extracted from Chinese medicine (CM) can not only alleviate pathological status but also promote health by anti-inflammatory, regulating immunity, lowering blood glucose and lipids, anti-cancer, and anti-oxidation. The alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides treatment. In addition, they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut microbiota. This review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics for promoting health. [ABSTRACT FROM AUTHOR]
- Subjects :
- LIPID metabolism
PREVENTION of chronic diseases
PREVENTION of obesity
POLYSACCHARIDES
LIPOPOLYSACCHARIDES
PREBIOTICS
ANTILIPEMIC agents
GUT microbiome
ANTI-inflammatory agents
NON-alcoholic fatty liver disease
BLOOD sugar
HYPOGLYCEMIC agents
ANTINEOPLASTIC agents
ANTIOXIDANTS
METABOLISM
TYPE 2 diabetes
IMMUNITY
DRUG synergism
PLANT extracts
CHINESE medicine
HEART failure
LIPIDS
SHORT-chain fatty acids
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 16720415
- Volume :
- 30
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Chinese Journal of Integrative Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 174971371
- Full Text :
- https://doi.org/10.1007/s11655-022-3522-y