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Comments on "Emerging insights and commentaries – MMRM vs LOCF by Naitee Ting".
- Source :
- Journal of Biopharmaceutical Statistics; 2024, Vol. 34 Issue 1, p146-148, 3p
- Publication Year :
- 2024
-
Abstract
- The article discusses the use of MMRM (Mixed Model for Repeated Measures) and LOCF (Last Observation Carried Forward) analysis strategies in the context of the ICH E9 (R1) estimands framework. The authors express concerns about the justification and conclusions presented by Ting, who argues for the broad adoption of LO analysis. They argue that the choice of estimation methods should be driven by the choice of estimands, which should be based on clinical rationale. They also disagree with Ting's assertion that LO analysis is superior and emphasize the importance of considering the clinical context when selecting estimation methods. [Extracted from the article]
- Subjects :
- TREATMENT effectiveness
PRAGMATICS
PRODUCT elimination
MISSING data (Statistics)
Subjects
Details
- Language :
- English
- ISSN :
- 10543406
- Volume :
- 34
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Biopharmaceutical Statistics
- Publication Type :
- Academic Journal
- Accession number :
- 174795893
- Full Text :
- https://doi.org/10.1080/10543406.2023.2250853