Strain‐Induced Heteromorphosis Multi‐Cavity Cages: Tension‐Driven Self‐Expansion Strategy for Controllable Enhancement of Complexity in Supramolecular Assembly.

Coordinative supramolecular cages with adjustable cavities have found extensive applications in various fields, but the cavity modification strategies for multi‐functional structures are still challenging. Here, we present a tension‐driven self‐expansion strategy for construction of multi‐cavity cages with high structural complexity. Under the regulation of strain‐induced capping ligands, unprecedented heteromorphosis triple‐cavity cages S2/S4 were obtained based on a metallo‐organic ligand (MOL) scaffold. The heteromorphosis cages exhibited significant higher cavity diversity than the homomorphous double‐cavity cages S1/S3; all of the cages were thoroughly characterized through various analytical techniques including (1D and 2D) NMR, ESI‐MS, TWIM‐MS, AFM, and SAXS analyses. Furthermore, the encapsulation of porphyrin in the cavities of these multi‐cavity cages were investigated. This research opens up new possibilities for the architecture of heteromorphosis supramolecular cages via precisely controlled "scaffold‐capping" assembly with preorganized ligands, which could have potential applications in the development of multifunctional structures with higher complexity. [ABSTRACT FROM AUTHOR]