Studies from Southwest University Reveal New Findings on Schizophrenia (Functional Connectome Hierarchy in Schizotypy and Its Associations With Expression of Schizophrenia-Related Genes).

A recent study conducted by researchers at Southwest University in Chongqing, China, explores the relationship between schizotypy and schizophrenia. Schizotypy is considered a continuum of symptoms that share genetic, neurobiological, and sensory-cognitive similarities with schizophrenia. The study utilized resting-state fMRI data from 1013 healthy young adults to investigate the connectome hierarchy associated with schizotypy and its similarity to the connectome hierarchy observed in schizophrenia. The findings suggest that schizotypy is associated with a compressed functional connectome hierarchy, which may contribute to sensory-cognition deficits. Additionally, the study provides insights into the neurobiological continuum of psychosis and the potential role of gene variation in mediating vulnerability to schizophrenia. [Extracted from the article]