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The Involvement of LAG-3 positive Plasma Cells in the Development of Multiple Myeloma.
- Source :
- International Journal of Molecular Sciences; Jan2024, Vol. 25 Issue 1, p549, 12p
- Publication Year :
- 2024
-
Abstract
- The Lymphocyte-Activation Protein 3 (LAG-3) inhibitory receptor is expressed on regulatory plasma cells (PCs). Micro-environmental cells that express LAG-3 were found to be increased during the progression of smoldering multiple myeloma (SMM). To assess the possible role of LAG-3 expression on regulatory PCs in patients with plasma cell dyscrasia. Purified Cluster of Differentiation 138 (CD138<superscript>+)</superscript> PCs from patients with premalignant conditions, active multiple myeloma (MM), and controls were analyzed for the expression of LAG-3 by flow cytometry. Autologous CD8<superscript>+</superscript>T cells were incubated with sorted LAG-3<superscript>pos</superscript> or LAG-3<superscript>neg</superscript> PCs for 24 h. The expression of granzyme (Grz) in CD8<superscript>+</superscript>T cells was assessed by flow cytometry. LAG-3 expression on PCs in active MM (newly diagnosed and relapse refractory MM) was significantly increased compared to monoclonal gammopathy of undetermined significance (MGUS)/ SMM. Grz expression was significantly decreased in CD8<superscript>+</superscript>T cells incubated with CD138<superscript>+</superscript>LAG-3<superscript>pos</superscript> PCs, compared to CD138<superscript>+</superscript>LAG-3<superscript>neg</superscript> PCs in patients with plasma cell dyscrasia, n = 31, p = 0.0041. LAG-3 expression on malignant PCs can be involved in the development of MM from MGUS by decreasing the expression of Grz in CD8<superscript>+</superscript>T cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16616596
- Volume :
- 25
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 174717307
- Full Text :
- https://doi.org/10.3390/ijms25010549