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Portal Hypertension in Malnutrition and Sarcopenia in Decompensated Cirrhosis—Pathogenesis, Implications and Therapeutic Opportunities.

Authors :
Terbah, Ryma
Testro, Adam
Gow, Paul
Majumdar, Avik
Sinclair, Marie
Source :
Nutrients; Jan2024, Vol. 16 Issue 1, p35, 21p
Publication Year :
2024

Abstract

Malnutrition and sarcopenia are highly prevalent in patients with decompensated cirrhosis and are associated with poorer clinical outcomes. Their pathophysiology is complex and multifactorial, with protein-calorie malnutrition, systemic inflammation, reduced glycogen stores and hormonal imbalances all well reported. The direct contribution of portal hypertension to these driving factors is however not widely documented in the literature. This review details the specific mechanisms by which portal hypertension directly contributes to the development of malnutrition and sarcopenia in cirrhosis. We summarise the existing literature describing treatment strategies that specifically aim to reduce portal pressures and their impact on nutritional and muscle outcomes, which is particularly relevant to those with end-stage disease awaiting liver transplantation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20726643
Volume :
16
Issue :
1
Database :
Complementary Index
Journal :
Nutrients
Publication Type :
Academic Journal
Accession number :
174714526
Full Text :
https://doi.org/10.3390/nu16010035