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Anti-Inflammatory Effects of Clematis terniflora Leaf on Lipopolysaccharide-Induced Acute Lung Injury.
- Source :
- Evidence-based Complementary & Alternative Medicine (eCAM); 1/9/2024, p1-11, 11p
- Publication Year :
- 2024
-
Abstract
- For centuries, natural products are regarded as vital medicines for human survival. Clematis terniflora var. mandshurica (Rupr.) Ohwi is an ingredient of the herbal medicine, Wei Ling Xian, which has been used in Chinese medicine to alleviate pain, fever, and inflammation. In particular, C. terniflora leaves have been used to cure various inflammatory diseases, including tonsillitis, cholelithiasis, and conjunctivitis. Based on these properties, this study aimed to scientifically investigate the anti-inflammatory effect of an ethanol extract of leaves of C. terniflora (EELCT) using activated macrophages that play central roles in inflammatory response. In this study, EELCT inhibited the essential inflammatory mediators, such as nitric oxide, cyclooxygenase-2, tumor necrosis factor-α, interleukin- (IL-) 6, IL-1β, and inducible nitric oxide synthase, by suppressing the nuclear factor-κB and mitogen-activated protein kinase activation in macrophages. Acute lung injury (ALI) is a fatal respiratory disease accompanied by serious inflammation. With high mortality rate, the disease has no effective treatments. Therefore, new therapeutic agents must be developed for ALI. We expected that EELCT can be a promising therapeutic agent for ALI by reducing inflammatory responses and evaluated its action in a lipopolysaccharide- (LPS-) induced ALI model. EELCT alleviated histological changes, immune cell infiltration, inflammatory mediator production, and protein-rich pulmonary edema during ALI. Collectively, our results may explain the traditional usage of C. terniflora in inflammatory diseases and suggest the promising potential of EELCT as therapeutic candidate for ALI. [ABSTRACT FROM AUTHOR]
- Subjects :
- LUNG injuries
LIPOPOLYSACCHARIDES
CYCLOOXYGENASE 2
INTERLEUKINS
STAINS & staining (Microscopy)
ANTI-inflammatory agents
WESTERN immunoblotting
NONSTEROIDAL anti-inflammatory agents
ONE-way analysis of variance
NF-kappa B
MACROPHAGES
LEAVES
ENZYME-linked immunosorbent assay
TUMOR necrosis factors
DESCRIPTIVE statistics
RESEARCH funding
PLANT extracts
MOLECULAR structure
NITRIC oxide
MITOGEN-activated protein kinases
DATA analysis software
ACUTE diseases
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Database :
- Complementary Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 174710371
- Full Text :
- https://doi.org/10.1155/2024/6653893