Characteristics of opportunistic infections in HIV-infected individuals with suboptimal immune reconstruction in Guangxi.

Objective To explore the characteristics of opportunistic infections (OIs) in HIV-infected individuals with suboptimal immune reconstitution after ART treatment so as to provide a reference for preventing and managing HIV infections. Methods The clinical data including opportunistic infections specifically were acquired from 112 HIV-infected individuals with suboptimal immune reconstitution from the outpatient department of Wuming Hospital, Guangxi Medical University. The impact of baseline CD4⁺T lymphocyte counts on the incidence, type, and mixed infection rates of the opportunistic infections were analyzed. Results The opportunistic infection rate among the 112 HIV-infected individuals with suboptimal immune reconstitution was 42.86%, among which fungal infections were the most commonly seen. The opportunistic infection rate of the patients with a baseline of CD4⁺T lymphocyte counts ≤ 50/μL was significantly higher than that of the patients with a baseline of CD4⁺T lymphocyte counts > 50/μL, and there was no significant difference in the type of opportunistic infections as well as the rate of mixed infections. Conclusion HIV-infected people with suboptimal immune reconstitution in Guangxi are susceptible to HIV OIs. Among them, the group with a baseline CD4⁺ T lymphocyte counts ≤ 50/μL has a higher rate of OIs, mainly fungal infections. [ABSTRACT FROM AUTHOR]