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Electrochemical detection of creatinine on Cu/carbon paper electrodes obtained by physical vapor deposition.
- Source :
- Journal of Applied Electrochemistry; Jan2024, Vol. 54 Issue 1, p115-126, 12p
- Publication Year :
- 2024
-
Abstract
- Creatinine is one of the most important biomarkers to detect renal failures. The electrochemical detection of creatinine has been performed using complex enzymatic and non-enzymatic electrode arrays hindering their commercialization. In this work, a new and practical non-enzymatic electrochemical sensor was fabricated depositing copper on carbon paper electrodes by physical vapor deposition (namely Cu/CP). Surface and cross-sectional SEM images demonstrated the deposition of copper over the 3D structure of carbon paper. A thin film was found on the surface, while Cu nanowires with diameters of 180 ± 30 nm were found inside the 3D structure of CP. The thickness of the Cu film on the tubular structures of CP was of 390 ± 40 nm. High-resolution TEM images indicated that the Cu film was integrated by hierarchical structures containing terminal Cu hemispheres of 17.6 ± 2.2 nm. Additionally, interplanar distances from the selected-area electron diffraction pattern demonstrated the presence of Cu<superscript>0</superscript>, while Cu<subscript>2</subscript>O was also found. Creatinine concentrations in saliva between 16 and 400 µM indicate kidney failure. The Cu/CP electrochemical sensor detected creatinine with linear concentration ranges from 0 to 1000 µM with a r<superscript>2</superscript> = 0.9936. Outstandingly, this sensor presented good reproducibility (RSD = 7.3%), and selectivity to detect creatinine in artificial saliva using interferents like urea, glucose, glycine, ascorbic and uric acids. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0021891X
- Volume :
- 54
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Applied Electrochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 174644995
- Full Text :
- https://doi.org/10.1007/s10800-023-01943-7