Back to Search
Start Over
Highlights of Cardiovascular Disease Prevention Studies Presented at the 2023 European Society of Cardiology Congress.
- Source :
- Current Atherosclerosis Reports; Dec2023, Vol. 25 Issue 12, p965-978, 14p
- Publication Year :
- 2023
-
Abstract
- Purpose of Review: To summarize selected late-breaking science on cardiovascular (CV) disease prevention presented at the 2023 European Society of Cardiology (ESC) congress. Recent Findings: The NATURE-PARADOX was a naturally randomized trial that used genetic data from the UK Biobank registry to create "cumulative exposure to low-density lipoprotein-cholesterol (LDL-C)" biomarker and evaluate its association with major CV events regardless of plasma LDL-C levels or age. Safety and efficacy data of inclisiran, a PCSK9-interfering mRNA (PCSK9i) administered subcutaneously twice annually, were presented. Data on two new PCSK9is were presented, recaticimab, an oral drug, and lerodalcibep, a subcutaneous drug with a slightly different architecture than currently available PSCK9is. A phase 1 trial on muvalaplin, an oral lipoprotein (a) inhibitor, was presented. An atherosclerotic CV disease (ASCVD) risk prediction algorithm for the Asian population using SCORE2 data was presented. Long-term follow-up of patients enrolled in the CLEAR outcomes trial showed sustained and more significant ASCVD risk reduction with bempedoic acid in high-risk patients. Summary: The late-breaking clinical science at the 2023 congress of the ESC extends the known safety and efficacy data of a PCSK9i with the introduction of new drugs in this class. Using cumulative exposure to LDL-C rather than a single value will help clinicians tailor the LDL-C reduction strategy to individual risk and is an important step towards personalized medicine. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15233804
- Volume :
- 25
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Current Atherosclerosis Reports
- Publication Type :
- Academic Journal
- Accession number :
- 174639159
- Full Text :
- https://doi.org/10.1007/s11883-023-01164-5