Findings on Hyperglycemia Discussed by Investigators at Vanderbilt University School of Medicine (Mechanism of Peroxidasin Inactivation In Hyperglycemia: Heme Damage By Reactive Oxygen Species).

A recent study conducted at Vanderbilt University School of Medicine in Nashville, Tennessee, explored the mechanisms of peroxidasin inactivation in hyperglycemia. The researchers found that glucose-induced oxidative degradation of heme led to the inhibition of peroxidasin activity, which plays a role in reinforcing basement membranes. This damage to extracellular proteins may compromise the structure and stability of basement membranes in diabetes. The findings suggest potential modes of protection and contribute to our understanding of diabetic complications. The study was supported by the NIH National Institute of Diabetes & Digestive & Kidney Diseases. [Extracted from the article]