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Amyotrophic lateral sclerosis and osteoporosis: a two-sample Mendelian randomization study.
- Source :
- Frontiers in Aging Neuroscience; 2023, p1-10, 10p
- Publication Year :
- 2023
-
Abstract
- Background: A few observational studies revealed that amyotrophic lateral sclerosis (ALS) was tightly connected with osteoporosis. However, the results of previous studies were inconsistent, and the causal effect of ALS on osteoporosis has not been investigated. To do so, the two-sample Mendelian randomization (MR) method was employed to estimate the causality. Methods: The instrumental variables (IVs) for ALS were selected from one GWAS summary dataset (27,205 ALS cases and 110,881 controls), and bone mineral density (BMD) in the femoral neck (FN), lumbar spine (LS), and forearm, extracted from another large-scale GWAS summary database (53,236 cases), were used as phenotypes for osteoporosis. Random-effects inverse variance weighted (IVW), MR Egger, weighted median, simple mode, and weighted mode were conducted to evaluate the causality. Sensitivity analyses were further performed to explore heterogeneity and pleiotropy. Results: A total of 10 qualified SNPs were finally selected as proxies for ALS. The results of random effects from IVW revealed that ALS has no causal effect on FN-BMD (beta: −0.038, 95% CI: −0.090 to 0.015, SE: 0.027, p = 0.158), LS-BMD (beta: −0.015, 95% CI: −0.076 to 0.046, SE: 0.031, p = 0.629), and forearm BMD (beta: 0.044, 95% CI: −0.063 to 0.152, SE: 0.055, p = 0.418). These results were confirmed using the MR-Egger, weighted median, simple model, and weighted model. No heterogeneity or pleiotropy was detected (p > 0.05 for all). Conclusion: Contrary to previous observational studies, our study figured out that no causal effect existed between ALS and osteoporosis. The disparity in results is probably attributed to secondary effects such as physical inactivity and muscle atrophy caused by ALS. [ABSTRACT FROM AUTHOR]
- Subjects :
- FOREARM
MUSCULAR atrophy
CONFIDENCE intervals
SINGLE nucleotide polymorphisms
ACQUISITION of data
CASE-control method
OSTEOPOROSIS
AMYOTROPHIC lateral sclerosis
MEDICAL records
DESCRIPTIVE statistics
MOLECULAR epidemiology
BONE density
FEMUR
LUMBAR vertebrae
EPIDEMIOLOGICAL research
PHENOTYPES
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 16634365
- Database :
- Complementary Index
- Journal :
- Frontiers in Aging Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 174516470
- Full Text :
- https://doi.org/10.3389/fnagi.2023.1305040