Short‐term fasting attenuates lipopolysaccharide/D‐galactosamine‐induced acute liver failure through Sirt1‐autophagy signaling in mice.

A study published in the journal MedComm explores the effects of short-term fasting on acute liver failure (ALF) induced by lipopolysaccharide (LPS) and D-galactosamine (D-GalN) in mice. The researchers found that 24-hour fasting significantly reduced liver injury and improved survival rates in mice. The fasting also suppressed hepatocyte apoptosis, or cell death, which is a major factor in liver failure. The study suggests that short-term fasting may be a potential therapeutic intervention for liver diseases and highlights the importance of the Sirt1-autophagy signaling pathway in this process. [Extracted from the article]