Reports from University of Leicester Highlight Recent Research in Medical Research Methodology (A systematic review of simulation studies which compare existing statistical methods to account for non-compliance in randomised controlled trials).

A recent report from the University of Leicester discusses the challenges of non-compliance in medical research and the methods used to address this issue. The report highlights the limited evidence supporting the use of certain methods and the potential bias that can result from a per protocol approach. The researchers conducted a systematic review of simulation studies to compare existing statistical methods and assess their performance under various scenarios. The review found that instrumental variable methods were commonly considered but often found to be biased in certain settings. The researchers concluded that more studies are needed to compare a wide range of methods in realistic scenarios and that it is difficult to determine the best method to deal with non-compliance due to the limited body of evidence. [Extracted from the article]