Reports on Diabetes Research Findings from Nantong University Provide New Insights (Lncrna Malat1 Regulates Ipsc-derived I3-cell Differentiation By Targeting the Mir-15b-5p/ihh Axis).

New research from Nantong University in China explores the differentiation of induced pluripotent stem cells (iPSCs)-derived I3-like cells as a potential treatment for type 1 diabetes. The study focuses on the regulatory mechanisms of long noncoding RNAs (lncRNAs) in these cells and their impact on the development of the pancreas and pancreatic I3-cells. The researchers found that the lncRNA Malat1 plays a role in impairing the differentiation and maturation of I3-like cells, and it may also regulate the expression of Ihh through its interaction with miR-15b-5p. The study suggests that lncRNA Malat1 could be a potential target for future diabetes treatments. [Extracted from the article]