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Probiotics and Prebiotics Orally Assumed as Disease Modifiers for Stable Mild Atopic Dermatitis: An Italian Real-Life, Multicenter, Retrospective, Observational Study.

Authors :
Colombo, Delia
Rigoni, Corinna
Cantù, Alessandra
Carnevali, Antonello
Filippetti, Rossella
Franco, Tiziana
Grassi, Alessandra
Loi, Camilla
Mazzotta, Annamaria
Patroi, Ivona
Raone, Beatrice
Tomassini, Marco Andrea
Amoruso, Angela
Pane, Marco
Damiani, Giovanni
Source :
Medicina (1010660X); Dec2023, Vol. 59 Issue 12, p2080, 9p
Publication Year :
2023

Abstract

The role of the skin–gut axis in atopic dermatitis (AD) remains a subject of debate, limiting non-pharmacological interventions such as probiotics and prebiotics. To improve understanding of their potential as a monotherapy for stable mild cases, we conducted a real-life, multicenter, retrospective observational study in Italy. We administered three selected bacteria (Bifidobacterium animalis subsp. lactis BS01, Lactiplantibacillus plantarum LP14, and Lacticaseibacillus rhamnosus LR05) orally to patients with mild atopic dermatitis without a placebo control group, following up for 12 weeks. Clinical assessments using the Scoring Atopic Dermatitis (SCORAD), Eczema Area and Severity Index (EASI), and Three-Item Severity (TIS) score were conducted on 144 enrolled patients (average age: 25.1 ± 17.6 years). Notably, both pruritus and AD-related lesions (erythema, edema/papules, excoriation) exhibited significant clinical and statistical improvement (p < 0.001) after 12 weeks of exclusive probiotic and prebiotic use. These preliminary results suggest a potential link between the skin–gut microbiome and support the rationale for using specific probiotics and prebiotics in mild AD, even for maintenance, to reduce flares and dysbiosis. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1010660X
Volume :
59
Issue :
12
Database :
Complementary Index
Journal :
Medicina (1010660X)
Publication Type :
Academic Journal
Accession number :
174465464
Full Text :
https://doi.org/10.3390/medicina59122080