Back to Search
Start Over
A CIE change in our understanding of endocytic mechanisms.
- Source :
- Frontiers in Cell & Developmental Biology; 2023, p1-7, 7p
- Publication Year :
- 2023
-
Abstract
- The past six decades have seen major advances in our understanding of endocytosis, ranging from descriptive studies based on electron microscopy to biochemical and genetic characterization of factors required for vesicle formation. Most studies focus on clathrin as the major coat protein; indeed, clathrinmediated endocytosis (CME) is the primary pathway for internalization. Clathrin-independent (CIE) pathways also exist, although mechanistic understanding of these pathways remains comparatively elusive. Here, we discuss how early studies of CME shaped our understanding of endocytosis and describe recent advances in CIE, including pathways in model organisms that are poised to provide key insights into endocytic regulation. [ABSTRACT FROM AUTHOR]
- Subjects :
- CLATHRIN
ENDOCYTOSIS
ELECTRON microscopy
Subjects
Details
- Language :
- English
- ISSN :
- 2296634X
- Database :
- Complementary Index
- Journal :
- Frontiers in Cell & Developmental Biology
- Publication Type :
- Academic Journal
- Accession number :
- 174459091
- Full Text :
- https://doi.org/10.3389/fcell.2023.1334798