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The ROSA-Like Prophage Colonizing Staphylococcus aureus Promotes Intracellular Survival, Biofilm Formation, and Virulence in a Chronic Wound Environment.
- Source :
- Journal of Infectious Diseases; Dec2023, Vol. 228 Issue 12, p1800-1804, 5p
- Publication Year :
- 2023
-
Abstract
- Background The transition from colonization to invasion is critical in diabetic foot ulcer (DFU). Staphylococcus aureus can colonize DFU, or invade the underlying tissues, causing serious infections. The ROSA-like prophage has previously been implicated in strain colonization characteristics of S aureus isolates in uninfected ulcers. Methods In this study, we investigated this prophage in the S aureus -colonizing strain using an in vitro chronic wound medium mimicking the chronic wound environment. Results Chronic wound medium reduced bacterial growth and increased biofilm formation and virulence in a zebrafish model. Conclusions The ROSA-like prophage promoted intracellular survival of S aureus -colonizing strain in macrophages, keratinocytes, and osteoblasts. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 228
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 174386510
- Full Text :
- https://doi.org/10.1093/infdis/jiad218