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Engineering yeast for the production of plant terpenoids using synthetic biology approaches.
- Source :
- Natural Product Reports; Dec2023, Vol. 40 Issue 12, p1822-1848, 27p
- Publication Year :
- 2023
-
Abstract
- Covering: 2011–2022 The low amounts of terpenoids produced in plants and the difficulty in synthesizing these complex structures have stimulated the production of terpenoid compounds in microbial hosts by metabolic engineering and synthetic biology approaches. Advances in engineering yeast for terpenoid production will be covered in this review focusing on four directions: (1) manipulation of host metabolism, (2) rewiring and reconstructing metabolic pathways, (3) engineering the catalytic activity, substrate selectivity and product specificity of biosynthetic enzymes, and (4) localizing terpenoid production via enzymatic fusions and scaffolds, or subcellular compartmentalization. [ABSTRACT FROM AUTHOR]
- Subjects :
- BIOENGINEERING
TERPENES
ENZYME specificity
CATALYTIC activity
SYNTHETIC biology
Subjects
Details
- Language :
- English
- ISSN :
- 02650568
- Volume :
- 40
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Natural Product Reports
- Publication Type :
- Academic Journal
- Accession number :
- 174199468
- Full Text :
- https://doi.org/10.1039/d3np00005b