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Physicochemical and in vitro Analysis of Herbal Drugs A. indica, C. longa, P. pinnata, P. corylifolia, W. fruticosa for Potential Effect in Psoriasis.

Authors :
Kumar, Arun
Singh, Saurabh
Kumar, Bimlesh
Wadhwa, Sheetu
Baghel, Dileep Singh
Panday, Narendra Kumar
Singh, Sachin Kumar
Shivani
Pal, Vikas Kumar
Source :
Pharmacognosy Research; Oct-Dec2023, Vol. 15 Issue 4, p831-840, 10p
Publication Year :
2023

Abstract

Background: Curcuma longa (Zingiberaceae), Azadirachta indica (Meliaceae), Psoralea corylifolia (Fabaceae), Pongamia pinnata (Fabaceae), and Woodfordia fruticosa (Lythraceae) stand as renowned medicinal plants in India. Traditionally, different parts of these plants have been employed for healing, particularly in the context of treating psoriasis and various other ailments. This catalyzed our investigation into the potential antipsoriatic properties of these botanicals. Objectives: We set out to evaluate the preliminary phytochemical analysis and in vitro antipsoriatic capabilities of acetone, ethanol, and water extracts derived from Curcuma longa, Azadirachta indica, Psoralea corylifolia, Pongamia pinnata, and Woodfordia fruticosa. Materials and Methods: The antipsoriatic potential of these extracts was assessed through the MTT assay, using HaCaT cells. Additionally, we conducted LDH assays and utilized confocal microscopy to gain further insights. Results: Our investigations unveiled the promising antiproliferative activity of these plants on skin keratinocytes. Notably, compounds A, B, and C demonstrated a significant decrease in cell viability compared to the control group. In contrast, compounds D and E did not exhibit significant differences compared to the control. Discussion and Conclusion: These findings substantiate the traditional uses of these plants in the treatment of psoriasis and underscore their potential as valuable resources in the quest for effective antipsoriatic treatments. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09764836
Volume :
15
Issue :
4
Database :
Complementary Index
Journal :
Pharmacognosy Research
Publication Type :
Academic Journal
Accession number :
174195016
Full Text :
https://doi.org/10.5530/pres.15.4.088