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Is System x c − a Suitable Target for Tumour Detection and Response Assessment with Imaging?
- Source :
- Cancers; Dec2023, Vol. 15 Issue 23, p5573, 15p
- Publication Year :
- 2023
-
Abstract
- Simple Summary: The expression of the cysteine–glutamate cotransporter, system x<subscript>c</subscript><superscript>−</superscript>, is increased in cancer cells across many cancer types. Imaging system x<subscript>c</subscript><superscript>−</superscript> provides new insights into tumour behaviour. The radiotracer (4S)-4-(3-[<superscript>18</superscript>F]Fluoropropyl)-L-glutamic acid (<superscript>18</superscript>F-FSPG) is specifically transported by system x<subscript>c</subscript><superscript>−</superscript>, allowing for a non-invasive method of measuring this transporter's activity. This review summarises the data available on the use of <superscript>18</superscript>F-FSPG in human cancer patients, exploring its advantages and disadvantages, and suggests possible future uses of <superscript>18</superscript>F-FSPG in the assessment of early treatment response and treatment resistance. System x<subscript>c</subscript><superscript>−</superscript> is upregulated in cancer cells and can be imaged using novel radiotracers, most commonly with (4S)-4-(3-[<superscript>18</superscript>F]fluoropropyl)-L-glutamic acid (<superscript>18</superscript>F-FSPG). The aim of this review was to summarise the use of <superscript>18</superscript>F-FSPG in humans, explore the benefits and limitations of <superscript>18</superscript>F-FSPG, and assess the potential for further use of <superscript>18</superscript>F-FSPG in cancer patients. To date, ten papers have described the use of <superscript>18</superscript>F-FSPG in human cancers. These studies involved small numbers of patients (range 1–26) and assessed the use of <superscript>18</superscript>F-FSPG as a general oncological diagnostic agent across different cancer types. These clinical trials were contrasting in their findings, limiting the scope of <superscript>18</superscript>F-FSPG PET/CT as a purely diagnostic agent, primarily due to heterogeneity of <superscript>18</superscript>F-FSPG retention both between cancer types and patients. Despite these limitations, a potential further application for <superscript>18</superscript>F-FSPG is in the assessment of early treatment response and prediction of treatment resistance. Animal models of cancer have shown that changes in <superscript>18</superscript>F-FSPG retention following effective therapy precede glycolytic changes, as indicated by <superscript>18</superscript>F-FDG, and changes in tumour volume, as measured by CT. If these results could be replicated in human clinical trials, imaging with <superscript>18</superscript>F-FSPG PET/CT would offer an exciting route towards addressing the currently unmet clinical needs of treatment resistance prediction and early imaging assessment of therapy response. [ABSTRACT FROM AUTHOR]
- Subjects :
- CYSTEINE metabolism
GLUTAMIC acid metabolism
TUMOR treatment
BIOLOGICAL models
RADIOISOTOPES
POSITRON emission tomography computed tomography
TREATMENT effectiveness
MOLECULAR biology
TUMORS
TUMOR markers
CELL lines
PREDICTION models
MOLECULAR structure
CARRIER proteins
DRUG resistance in cancer cells
EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 20726694
- Volume :
- 15
- Issue :
- 23
- Database :
- Complementary Index
- Journal :
- Cancers
- Publication Type :
- Academic Journal
- Accession number :
- 174115322
- Full Text :
- https://doi.org/10.3390/cancers15235573