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Antioxidant peptides, the guardian of life from oxidative stress.

Authors :
Zhu, Yiyun
Wang, Kang
Jia, Xinyi
Fu, Caili
Yu, Haining
Wang, Yipeng
Source :
Medicinal Research Reviews; Jan2024, Vol. 44 Issue 1, p275-364, 90p
Publication Year :
2024

Abstract

Reactive oxygen species (ROS) are produced during oxidative metabolism in aerobic organisms. Under normal conditions, ROS production and elimination are in a relatively balanced state. However, under internal or external environmental stress, such as high glucose levels or UV radiation, ROS production can increase significantly, leading to oxidative stress. Excess ROS production not only damages biomolecules but is also closely associated with the pathogenesis of many diseases, such as skin photoaging, diabetes, and cancer. Antioxidant peptides (AOPs) are naturally occurring or artificially designed peptides that can reduce the levels of ROS and other pro‐oxidants, thus showing great potential in the treatment of oxidative stress‐related diseases. In this review, we discussed ROS production and its role in inducing oxidative stress‐related diseases in humans. Additionally, we discussed the sources, mechanism of action, and evaluation methods of AOPs and provided directions for future studies on AOPs. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01986325
Volume :
44
Issue :
1
Database :
Complementary Index
Journal :
Medicinal Research Reviews
Publication Type :
Academic Journal
Accession number :
174108807
Full Text :
https://doi.org/10.1002/med.21986