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Associations Between Longitudinal Loneliness, DNA Methylation Age Acceleration, and Cognitive Functioning.
- Source :
- Journals of Gerontology Series B: Psychological Sciences & Social Sciences; Dec2023, Vol. 78 Issue 12, p2045-2059, 15p
- Publication Year :
- 2023
-
Abstract
- Objectives Loneliness may influence aging biomarkers related to cognitive functioning, for example, through accelerated DNA methylation (DNAm) aging. Methods In the present study, we tested whether six common DNAm age acceleration measures mediated the effects of baseline loneliness and five different longitudinal loneliness trajectories on general cognitive ability, immediate memory recall, delayed memory recall, and processing speed in 1,814 older adults in the Health and Retirement Study. Results We found that baseline loneliness and individuals who belong to the highest loneliness trajectories had poorer general cognitive ability and memory scores. Only DNAm age acceleration measures that index physiological comorbidities, unhealthy lifestyle factors (e.g. smoking), and mortality risk-mediated effects of baseline loneliness on general cognitive ability and memory functioning but not processing speed. These same DNAm measures mediated effects of the moderate-but-declining loneliness trajectory on cognitive functioning. Additionally, immediate and delayed memory scores were mediated by GrimAge Accel in the lowest and two highest loneliness trajectory groups. Total and mediated effects of loneliness on cognitive functioning outcomes were mainly accounted for by demographic, social, psychological, and physiological covariates, most notably self-rated health, depressive symptomatology, objective social isolation, and body mass index. Discussion Current findings suggest that DNAm biomarkers of aging, particularly GrimAge Accel, have promise for explaining the prospective association between loneliness and cognitive functioning outcomes. [ABSTRACT FROM AUTHOR]
- Subjects :
- MORTALITY risk factors
BIOMARKERS
MEMORY
RESEARCH
LIFESTYLES
COGNITIVE processing speed
SELF-evaluation
HEALTH status indicators
DNA methylation
SOCIAL isolation
LONELINESS
AGING
SHORT-term memory
RESEARCH funding
FACTOR analysis
DESCRIPTIVE statistics
MENTAL depression
COGNITIVE testing
STATISTICAL correlation
SMOKING
SOCIODEMOGRAPHIC factors
BODY mass index
COMORBIDITY
EPIGENOMICS
OLD age
Subjects
Details
- Language :
- English
- ISSN :
- 10795014
- Volume :
- 78
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Journals of Gerontology Series B: Psychological Sciences & Social Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 174108210
- Full Text :
- https://doi.org/10.1093/geronb/gbad128