SYNTHESIS, CHARACTERIZATION, ELECTROCHEMICAL AND ANTIBACTERIAL STUDIES OF MN4-TYPE MACROCYCLIC COMPLEXES OF NI(II).

Herein, we designed and synthesized two novel MN4-type macrocyclic complexes of NiII using a simple template-based strategy. The synthesized macrocyclic complexes were characterized by using several analytical techniques such as elemental analysis, FT-IR spectroscopy, UV-Vis spectroscopy, and mass spectrometry. The molar conductance was also measured to predict the electrolytic behavior of macrocyclic complexes. Furthermore, the complexes were subjected to electrochemical investigation utilizing cyclic voltammetric techniques. The results indicated a quasi-reversible peak for Ni^II/Ni^I redox couple with Ep value is 0.195 V and E_1/2 value of -0.749 V vs Ag/AgCl electrode. The complexes stabilized the unusual oxidation state of the central metal ion. In addition, both complexes were tested for their antibacterial activities against pathogens like E. coli, S. aureus, B. subtilis, C. albicans, and P. aeruginosa, and both complexes were shown to have comparable antibacterial activity with the standard drug Gentamycin. [ABSTRACT FROM AUTHOR]