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Impact of switching prophylaxis treatment from factor VIII to emicizumab in hemophilia A patients without inhibitors.
- Source :
- Journal of Medical Economics; Jan-Dec2023, Vol. 26 Issue 1, p574-580, 7p
- Publication Year :
- 2023
-
Abstract
- Factor VIII (FVIII) replacement and emicizumab are effective at preventing bleeds in patients with hemophilia A (HA). Though benefits of emicizumab among inhibitor patients with HA (PwHA) are well established, more real-world evidence among non-inhibitor patients is needed. Using a United States healthcare claims database, we compared billed annualized bleed rates (ABR<subscript>b</subscript>) and the total cost of care (TCC) before and after switching from FVIII prophylaxis to emicizumab among non-inhibitor male PwHA. Bayesian inferences were used to assess the difference in ABR<subscript>b</subscript> and TCC per patient per year (PPPY) pre- versus post-prophylaxis switch. We included 101 non-inhibitor male PwHA aged between 3 and 63 years old who switched from FVIII prophylaxis to emicizumab prophylaxis in 2018 or 2019. The ABR<subscript>b</subscript> increased from 0.52 to 0.62 (p = 0.83) after switch. The posterior probability of the mean ABR<subscript>b</subscript> increasing after the switch was 75.54%. The TCC PPPY increased from $517,143 to $627,005 (p < 0.0001) after switch and the posterior probability of mean costs increasing after the switch was 99.80%. Personalization of care through the identification of the most appropriate therapy for each patient can optimize clinical and economic outcomes. Future real-world evidence research could help establish the value of prophylactic options in targeted populations such as the non-inhibitor male PwHA. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13696998
- Volume :
- 26
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Medical Economics
- Publication Type :
- Academic Journal
- Accession number :
- 174083496
- Full Text :
- https://doi.org/10.1080/13696998.2023.2196922