Shanxi Medical University Researchers Broaden Understanding of Chronic Myeloid Leukemia (The role of CSE1L silencing in the regulation of proliferation and apoptosis via the AMPK/mTOR signaling pathway in chronic myeloid leukemia).

Researchers from Shanxi Medical University in China have conducted a study on chronic myeloid leukemia (CML) to investigate the expression and role of the protein CSE1L in this disease. The study found that CSE1L was highly expressed in bone marrow granulocytes of CML patients and that its knockdown inhibited cell proliferation, induced cell cycle arrest, and promoted apoptosis in CML cells. The researchers also observed changes in the expression of proteins involved in the AMPK/mTOR signaling pathway. These findings suggest that CSE1L plays a crucial role in the survival and growth of CML cells and may have implications for the treatment of CML patients. [Extracted from the article]