New Enzyme Inhibition and Medicinal Chemistry Findings from Jouf University Published (Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic...).

Researchers at Jouf University in Sakaka, Saudi Arabia have developed a series of antipyrine derivatives that show potential as non-acidic anti-inflammatory agents. The compounds were tested for their ability to inhibit COX-2 enzymes, with compounds 4b-d and 8d found to be the most potent. Further investigation focused on compounds 4b and 4c, which demonstrated the ability to counteract carrageenan-induced paw edema in vivo. The study also utilized molecular docking simulations to validate the results. This research provides valuable insights into the design and synthesis of new anti-inflammatory agents. [Extracted from the article]