Studies from University of Yamanashi Further Understanding of Thrombosis [C-type lectin-like receptor-2 (CLEC-2) is a key regulator of kappa-carrageenan-induced tail thrombosis model in mice].

A recent study conducted by researchers at the University of Yamanashi in Japan explored the molecular basis of thrombosis induced by kappa-carrageenan (KCG) in mice. The study found that KCG triggers platelet aggregation and activates integrin aIIbb3, leading to thrombosis. The researchers also discovered that C-type lectin-like receptor-2 (CLEC-2) plays a crucial role in KCG-induced platelet activation. These findings provide valuable insights into the mechanisms of thrombosis and could contribute to the development of new antithrombotic drugs. [Extracted from the article]