Researchers from University of California San Diego (UCSD) Provide Details of New Studies and Findings in the Area of Cancer (Scrambling the Genome In Cancer: Causes and Consequences of Complex Chromosome Rearrangements).

A recent study conducted by researchers from the University of California San Diego (UCSD) has provided new insights into the causes and consequences of complex chromosome rearrangements in cancer. The study focused on a type of rearrangement called chromothripsis, which involves massive and localized rearrangements of one or a few chromosomes. The researchers found that chromothripsis can be initiated by mitotic errors, leading to the inactivation of tumor suppressor genes, activation of proto-oncogenes, or gene amplification. The study also highlighted the link between chromothripsis and extrachromosomal DNA. This research has been peer-reviewed and published in Nature Reviews Genetics. [Extracted from the article]