Study Results from Shanghai Jiao Tong University School of Medicine Update Understanding of Cancer (M2 macrophage-derived exosomes suppress tumor intrinsic immunogenicity to confer immunotherapy resistance).

A study conducted by researchers at Shanghai Jiao Tong University School of Medicine in China has found that immunosuppressive M2 macrophages can make cancer cells resistant to immune checkpoint blockade therapy (ICB) by secreting exosomes. These exosomes transmit apolipoprotein E (ApoE) to cancer cells, which downregulates MHC-I expression and reduces tumor intrinsic immunogenicity. The researchers suggest that ApoE could serve as a predictor and potential therapeutic target for ICB resistance in cancer patients with M2 macrophage enrichment. They propose that treating M2-enriched tumors with an ApoE ligand, EZ-482, could restore sensitivity to ICB immunotherapy. [Extracted from the article]