Emerging trends in clinical cancer genomic research.

This article provides an overview of emerging trends in clinical cancer genomic research, with a specific focus on gastric cancer. It discusses four key trends in gastric cancer research, including the shift towards a reference pangenome-based methodology, cross-race studies, microenvironment-combined research, and the use of third-generation sequencing with long reads. The article also presents findings from studies on genetic variations in gastric cancer, the impact of patient ethnicity on gene mutations, and the role of the tumor microenvironment in peritoneal metastasis. These trends and findings offer valuable insights for genetic intervention treatment and clinical medication. The article also explores the use of omental neutrophils and peritoneal resident macrophages in promoting peritoneal metastasis and suggests blocking Tim-4 as a potential treatment strategy. It further discusses the use of The Cancer Genome Atlas (TCGA) database to identify mutated genes associated with vascular metastasis in gastric cancer, as well as the use of genomic sequencing techniques for disease diagnosis and the detection of structural variants. The article concludes by acknowledging the limitations and challenges of these technologies in clinical use. [Extracted from the article]