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Osteonecrosis of the jaw under palbociclib: A case series description.
- Source :
- Journal of Oncology Pharmacy Practice; Dec2023, Vol. 29 Issue 8, p1990-1997, 8p
- Publication Year :
- 2023
-
Abstract
- Introduction: Cases of osteonecrosis of the jaw have been reported by dental surgeons to the pharmacovigilance center in Rennes, France, occurring among patients treated with palbociclib, a cyclin-dependent kinase 4/6 inhibitor. Although this event was not expected with the drug, a safety signal was raised. Describing a local case series, the aim of our study was to identify specific patterns that might suggest a triggering role for these drugs, and to discuss pathophysiological hypotheses. Materials and methods: A retrospective case series of patients exposed to cyclin-dependent kinase 4/6 inhibitors between 2016 and 2020 with a diagnosis of osteonecrosis of the jaw at the Rennes Dental Care Center was analyzed. The descriptive analysis was conducted on patient demographics, breast cancer characteristics, osteonecrosis of the jaw, biological data, and exposure to cyclin-dependent kinase 4/6 inhibitors. Results: We identified eight cases, most of them at stages 0–1 (62.5%). Four patients were still exposed to palbociclib at the time of diagnosis and four had discontinued the treatment before the diagnosis. Chronological imputability could not be excluded given the drug's half-life and the variable intervals of dental monitoring from one patient to another. All patients had at least one dental osteonecrosis risk factor (including dental extraction, dentures, and denosumab exposure at the time of diagnosis). Neutropenia and mucositis were not systematically reported at the time of diagnosis. The anatomopathological characteristics were nonspecific. Conclusion: We did not identify a specific pattern that could suggest a triggering role of palbociclib in the development of ONJ. [ABSTRACT FROM AUTHOR]
- Subjects :
- THERAPEUTIC use of monoclonal antibodies
OSTEONECROSIS
DENTAL facilities
DENTURES
LEUCOPENIA
PROTEIN kinase inhibitors
PHARMACOLOGY
METASTASIS
RETROSPECTIVE studies
DENTAL extraction
ACQUISITION of data
NEUTROPENIA
CYCLIN-dependent kinases
COMPARATIVE studies
CASE studies
DESCRIPTIVE statistics
MEDICAL records
JAWS
HORMONE receptor positive breast cancer
DRUG toxicity
CHEMICAL inhibitors
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 10781552
- Volume :
- 29
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Journal of Oncology Pharmacy Practice
- Publication Type :
- Academic Journal
- Accession number :
- 173948725
- Full Text :
- https://doi.org/10.1177/10781552231165434