Findings from Wuhan Polytechnic University Provide New Insights into Pancreatic Cancer (Mir-122-5p Restrains Pancreatic Cancer Cell Growth and Causes Apoptosis By Negatively Regulating Asct2).

A study conducted at Wuhan Polytechnic University in China has found that a specific microRNA, miR-122-5p, may function as a tumor suppressor in pancreatic cancer cells. The study discovered that miR-122-5p inhibits cell proliferation, induces apoptosis, and alters the expression of the ASC amino acid transporter-2 (ASCT2), which is associated with poor prognosis in pancreatic cancer. These findings provide new insights into the regulatory mechanisms of ASCT2 expression and suggest a potential therapeutic target for pancreatic cancer treatment. The study was supported by various organizations, including the National Natural Science Foundation of China and the Health and Family Planning Commission of Hubei Province. [Extracted from the article]