Researchers from Jinzhou Medical University Report Findings in Rheumatoid Arthritis (A Targeted Exosome Therapeutic Confers Both Cfdna Scavenging and Macrophage Polarization for Ameliorating Rheumatoid Arthritis).

A study conducted by researchers from Jinzhou Medical University in China explores the role of cell-free DNA (cfDNA) in rheumatoid arthritis (RA) and the development of new therapeutics. The study reveals strong correlations between cfDNA levels, inflammatory response, and RA disease activity. The researchers developed a novel therapeutic using anti-inflammatory macrophage-derived exosomes that are modified with oligolysine and matrix metalloproteinase (MMP)-cleavable polyethylene glycol (PEG). This therapeutic demonstrated the ability to suppress inflammation, provide chondroprotection, and osteoprotection in animal models of RA, suggesting its potential for effective treatment. [Extracted from the article]