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Case report: A patient with Delayed Sleep-Wake Phase Disorder and Optic Nerve Hypoplasia treated with tasimelteon: a case study.

Authors :
Smieszek, Sandra P.
Kaden, Alyssa R.
Johnson, Caroline E.
Brzezynski, Jennifer L.
Xiao, Changfu
Polymeropoulos, Christos M.
Birznieks, Gunther
Emsellem, Helene A.
Polymeropoulos, Mihael H.
Source :
Frontiers in Neuroscience; 2023, p01-05, 5p
Publication Year :
2023

Abstract

We present a case of an adult female diagnosed with Delayed Sleep-Wake Phase Disorder (DSWPD) and Optic Nerve Hypoplasia (ONH), with a confirmed delayed Dim Light Melatonin Onset (DLMO), who reports the inability to fall asleep at their desired bedtime and obtain adequate sleep nightly, despite the ability to have a full night's sleep when not required to be up at a specific time for societal requirements. The participant was enrolled in an 11-month Open-Label Extension (OLE) following the randomized portion of a clinical study and was successfully treated with tasimelteon. DSWPD symptoms were resolved, and their previously delayed sleep-wake cycle was advanced. Clinical trial registration: https://clinicaltrials.gov/ct2/show/NCT04652882, identifier NCT04652882. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16624548
Database :
Complementary Index
Journal :
Frontiers in Neuroscience
Publication Type :
Academic Journal
Accession number :
173900370
Full Text :
https://doi.org/10.3389/fnins.2023.1287514