Back to Search
Start Over
Metabolomic Insights into the Mechanisms of Ganoderic Acid: Protection against α-Amanitin-Induced Liver Injury.
- Source :
- Metabolites (2218-1989); Nov2023, Vol. 13 Issue 11, p1164, 16p
- Publication Year :
- 2023
-
Abstract
- α-Amanitin is a representative toxin found in the Amanita genus of mushrooms, and the consumption of mushrooms containing α-Amanitin can lead to severe liver damage. In this study, we conduct toxicological experiments to validate the protective effects of Ganoderic acid A against α-amanitin-induced liver damage. By establishing animal models with different durations of Ganoderic acid A treatment and conducting a metabolomic analysis of the serum samples, we further confirmed the differences in serum metabolites between the AMA+GA and AMA groups. The analysis of differential serum metabolites after the Ganoderic acid A intervention suggests that Ganoderic acid A may intervene in α-amanitin-induced liver damage by participating in the regulation of retinol metabolism, tyrosine and tryptophan biosynthesis, fatty acid biosynthesis, sphingosine biosynthesis, spermidine and spermine biosynthesis, and branched-chain amino acid metabolism. This provides initial insights into the protective intervention mechanisms of GA against α-amanitin-induced liver damage and offers new avenues for the development of therapeutic drugs for α-Amanitin poisoning. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22181989
- Volume :
- 13
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Metabolites (2218-1989)
- Publication Type :
- Academic Journal
- Accession number :
- 173863977
- Full Text :
- https://doi.org/10.3390/metabo13111164