Associations of Long-Term Exposure to PM 2.5 and Its Constituents with Erythrocytosis and Thrombocytosis in Rural Populations.

Evidence on the effect of long-term exposure to fine particulate matter (PM_2.5) on erythrocytosis and thrombocytosis prevalence was limited. We aimed to investigate the association of PM_2.5 and its constituents with the risks of erythrocytosis and thrombocytosis. The present study included a total of 33,585 participants from the Henan Rural Cohort at baseline between 2015 and 2017. A hybrid satellite-based model was employed to estimate the concentrations of PM_2.5 mass and its constituents (including black carbon [BC], nitrate [NO₃⁻], ammonium [NH₄⁺], inorganic sulfate [SO₄²⁻], organic matter [OM], and soil particles [SOIL]). The logistic regression model was used to assess the associations of single exposure to PM_2.5 and its constituents with the risks of erythrocytosis and thrombocytosis, and the quantile G-computation method was applied to evaluate their joint exposure risk. For the independent association, the odds ratios for erythrocytosis/thrombocytosis with 1 μg/m³ increase was 1.049/1.043 for PM_2.5 mass, 1.596/1.610 for BC, 1.410/1.231 for NH₄⁺, 1.205/1.139 for NO₃⁻, 1.221/1.359 for OM, 1.300/1.143 for SO₄²⁻, and 1.197/1.313 for SOIL. Joint exposure to PM_2.5 and its components was also positively associated with erythrocytosis and thrombocytosis. The estimated weight of NH₄⁺ was found to be the largest for erythrocytosis, while OM had the largest weight for thrombocytosis. PM_2.5 mass and its constituents were positively linked to prevalent erythrocytosis and thrombocytosis, both in single-exposure and joint-exposure models. Additionally, NH₄⁺/OM was identified as a potentially responsible component for the association between PM_2.5 and erythrocytosis/thrombocytosis. [ABSTRACT FROM AUTHOR]