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Impact of autologous platelet concentrates on wound area reduction: A meta‐analysis of randomized controlled trials.
- Source :
- International Wound Journal; Dec2023, Vol. 20 Issue 10, p4384-4393, 10p
- Publication Year :
- 2023
-
Abstract
- This meta‐analysis aimed to evaluate the impact of autologous platelet concentrates (APCs) on wound area reduction based on randomized controlled trials (RCTs). A comprehensive search was conducted in PubMed, Embase, China National Knowledge Infrastructure (CNKI), Web of Science, and the Cochrane Library to identify relevant literature. The primary outcome measure was the percentage of wound area reduction. Secondary outcome measures included wound healing time and the incidence of infection. A total of 14 studies were included in the meta‐analysis. The results showed that the percentage of wound area reduction was significantly greater in the APCs group compared to conventional treatments (standardized mean difference [SMD] 1.98, 95% confidence interval [CI]: 1.27–2.68, p < 0.001). Subgroup analysis revealed that the percentage of wound area reduction varied based on wound location, follow‐up duration, and type of APCs used. The healing time and incidence of infection presented no significant difference between the two groups. The findings suggest that APCs can effectively reduce wound areas when compared to conventional treatments, without increasing the risk of infection. In addition, the effectiveness of APCs in wound area reduction may vary depending on factors such as wound location, type of APCs used, and follow‐up duration. [ABSTRACT FROM AUTHOR]
- Subjects :
- WOUND care
PLATELET-rich plasma
WOUND healing
ONLINE information services
MEDICAL databases
PATIENT aftercare
META-analysis
MEDICAL information storage & retrieval systems
CONFIDENCE intervals
SYSTEMATIC reviews
TREATMENT duration
TREATMENT effectiveness
INFECTION
DESCRIPTIVE statistics
RESEARCH funding
MEDLINE
EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 17424801
- Volume :
- 20
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- International Wound Journal
- Publication Type :
- Academic Journal
- Accession number :
- 173848928
- Full Text :
- https://doi.org/10.1111/iwj.14310