Research Data from Tabriz University of Medical Sciences Update Understanding of Tumor Necrosis Factors (trans-Chalcone protects male rats against high-fat emulsion-induced pancreatic injury by inhibiting TNF-a and MCP-1 expression).

A recent study conducted by researchers at Tabriz University of Medical Sciences in Iran explored the effects of trans-Chalcone, a compound found in chalcones, on pancreatic abnormalities induced by a high-fat diet in male rats. The study found that high-fat emulsion increased the expression levels of inflammatory biomarkers, including tumor necrosis factor a (TNF-a) and monocyte chemoattractant protein-1 (MCP-1), in the pancreas of rats. However, treatment with trans-Chalcone prevented these changes, suggesting that it has anti-inflammatory effects and can protect against high-fat diet-induced pancreatic abnormalities. The study highlights the potential of trans-Chalcone as a therapeutic agent for pancreatic inflammation caused by a high-fat diet. [Extracted from the article]