Researcher at Shandong University Describes Research in Spinal Cord Injury (Restoring neuronal iron homeostasis revitalizes neurogenesis after spinal cord injury).

A recent report from Shandong University in China discusses the potential for revitalizing neurogenesis after spinal cord injury (SCI) by restoring neuronal iron homeostasis. The researchers found that SCI can lead to iron overloading and hinder the recovery of locomotor function. By regulating cellular iron homeostasis through the use of polyphenol-based hydrogels, the researchers were able to promote neural stem/progenitor cell differentiation into neurons and improve axon reinnervation and remyelination. The use of these hydrogels significantly increased neurological motor scores and restored the transmission of sensory and motor electrophysiological signals after SCI. This research provides a promising approach for treating iron accumulation-related nervous system diseases. [Extracted from the article]