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Consistent effects of the genetics of happiness across the lifespan and ancestries in multiple cohorts.
- Source :
- Scientific Reports; 11/18/2023, Vol. 13 Issue 1, p1-8, 8p
- Publication Year :
- 2023
-
Abstract
- Happiness is a fundamental human affective trait, but its biological basis is not well understood. Using a novel approach, we construct LDpred-inf polygenic scores of a general happiness measure in 2 cohorts: the Adolescent Brain Cognitive Development (ABCD) cohort (N = 15,924, age range 9.23–11.8 years), the Add Health cohort (N = 9129, age range 24.5–34.7) to determine associations with several well-being and happiness measures. Additionally, we investigated associations between genetic scores for happiness and brain structure in ABCD (N = 9626, age range (8.9–11) and UK Biobank (N = 16,957, age range 45–83). We detected significant (p.FDR < 0.05) associations between higher genetic scores vs. several well-being measures (best r<superscript>2</superscript> = 0.019) in children of multiple ancestries in ABCD and small yet significant correlations with a happiness measure in European participants in Add Health (r<superscript>2</superscript> = 0.004). Additionally, we show significant associations between lower genetic scores for happiness with smaller structural brain phenotypes in a white British subsample of UK Biobank and a white sub-sample group of ABCD. We demonstrate that the genetic basis for general happiness level appears to have a consistent effect on happiness and wellbeing measures throughout the lifespan, across multiple ancestral backgrounds, and multiple brain structures. [ABSTRACT FROM AUTHOR]
- Subjects :
- HAPPINESS
NEURAL development
BRAIN anatomy
WELL-being
COGNITIVE development
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 13
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Scientific Reports
- Publication Type :
- Academic Journal
- Accession number :
- 173738477
- Full Text :
- https://doi.org/10.1038/s41598-023-43193-9