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Pathogenesis of Aerosolized Ebola Virus Variant Makona in Nonhuman Primates.
- Source :
- Journal of Infectious Diseases; 2023 Supplement, Vol. 228, pS604-S616, 13p
- Publication Year :
- 2023
-
Abstract
- Background Highly pathogenic filoviruses such as Ebola virus (EBOV) hold capacity for delivery by artificial aerosols, and thus potential for intentional misuse. Previous studies have shown that high doses of EBOV delivered by small-particle aerosol cause uniform lethality in nonhuman primates (NHPs), whereas only a few small studies have assessed lower doses in NHPs. Methods To further characterize the pathogenesis of EBOV infection via small-particle aerosol, we challenged cohorts of cynomolgus monkeys with low doses of EBOV variant Makona, which may help define risks associated with small particle aerosol exposures. Results Despite using challenge doses orders of magnitude lower than previous studies, infection via this route was uniformly lethal across all cohorts. Time to death was delayed in a dose-dependent manner between aerosol-challenged cohorts, as well as in comparison to animals challenged via the intramuscular route. Here, we describe the observed clinical and pathological details including serum biomarkers, viral burden, and histopathological changes leading to death. Conclusions Our observations in this model highlight the striking susceptibility of NHPs, and likely humans, via small-particle aerosol exposure to EBOV and emphasize the need for further development of diagnostics and postexposure prophylactics in the event of intentional release via deployment of an aerosol-producing device. [ABSTRACT FROM AUTHOR]
- Subjects :
- EBOLA virus
KRA
PRIMATES
PATHOGENESIS
AEROSOLS
MASS spectrometers
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 228
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 173720564
- Full Text :
- https://doi.org/10.1093/infdis/jiad137