Findings from University of Amsterdam in the Area of Atrial Fibrillation Reported (Micrornas In Atrial Fibrillation Target Genes In Structural Remodelling).

A recent study conducted by researchers at the University of Amsterdam aimed to understand how microRNAs (miRNAs) regulate the mRNA signature of atrial fibrillation (AF) and identify potential targets for future therapies. The study involved sequencing miRNAs and mRNAs in atrial tissues from patients with and without AF. The researchers discovered several key downregulated and upregulated miRNAs that were associated with changes in gene expression related to cell migration and glycosaminoglycan biosynthesis. These findings suggest that the identified miRNAs could be explored as potential targets for anti-fibrotic therapies in AF. The research was supported by the Netherlands Organization for Health Research and Development. [Extracted from the article]