Study Results from Ivanovo State University Update Understanding of Pyridoxal Therapy (Prediction of Protonation Constants of Hydrazones and Schiff Bases Derived From Pyridoxal 5′-phosphate, Pyridoxal, 3-hydroxyisonicotinaldehyde and...).

A recent study conducted at Ivanovo State University in Russia focused on the protonation constants of hydrazones and Schiff bases derived from pyridoxal, pyridoxal 5'-phosphate, 3-hydroxyisonicotinaldehyde, and salicylic aldehyde. These compounds have various biological activities and are used in areas such as analytical chemistry and medicine. The researchers developed a chemometric model to describe the protolytic equilibria constants, taking into account molecular descriptors and ionic strength. The protonation constants determined in this study can be used in further investigations of the coordination equilibria of these compounds. [Extracted from the article]