테리파라타이드를 투여한 골다공증성 척추압박골절 환자에서 압박 진행에 영향을 끼치는 자기공명영상 요인 분석.

Purpose: This study examined the correlation between the magnetic resonance imaging (MRI) findings and the progression of vertebral collapse in patients with osteoporotic vertebral fracture treated with teriparatide. Materials and Methods: Sixty patients (5 male, 55 female) who were followed-up for at least three months and diagnosed with osteoporotic vertebral fracture from January 2018 to October 2021, and treated with conservative therapies, such as bed rest and thoracolumbar-sacral orthosis, were enrolled in this study. All patients underwent magnetic resonance imaging soon after the fracture. The initial magnetic resonance images of the patients were reviewed retrospectively. The size of the vertebral low-intensity zone (LIZ) and fractures on the upper and lower endplates of the injured vertebrae were measured in the initial magnetic resonance imaging. Age and bone mineral density were also investigated. The correlation between the factors and the degree of progression of vertebral collapse obtained from plain radiograph imaging was studied. Results: The compression rate was increased significantly to 11.66%±7.33% in the group with the initial low-intensity zone (75%–100%) (p=0.001). The increase in compression rate was 16.33%±6.83% in the upper endplate fracture group, and 15.00%±7.07% in the upper and lower endplates fracture group, which was significantly higher than that in the absence of the endplate fracture group (p<0.001). Conclusion: In patients with osteoporotic vertebral fracture treated with teriparatide, the progression of the compression rate more likely increased when there was superior endplate fracture or superior and inferior endplate fracture and when there was a larger size of the lowintensity zone at the initial magnetic resonance imaging after fracture. [ABSTRACT FROM AUTHOR]