Protein expression of SARS‐CoV‐2 receptors ACE2 and TMPRSS2 in allergic airways after allergen challenge.

This article examines the protein expression of ACE2 and TMPRSS2 receptors in the airways of individuals with allergic asthma and allergic rhinitis after allergen challenge. The study found that allergen challenge led to a significant reduction in the number of cells expressing ACE2 and TMPRSS2 receptors in the bronchial tissue of individuals with allergic asthma. However, no significant changes were observed in the nasal tissue of individuals with allergic rhinitis. The authors hypothesized that elevated levels of IL-13, a type 2 cytokine, after allergen challenge may regulate ACE2 protein expression in the airways. The study suggests that while IL-13 may dampen ACE2 and TMPRSS2 receptor expression, other factors contribute to the rate of SARS-CoV-2 infectivity and hospitalization in individuals with asthma. [Extracted from the article]