Sun Yat-Sen University Researcher Reports Research in Nerve Injury (Deactivation of dorsal CA1 pyramidal neurons projecting to medial prefrontal cortex contributes to neuropathic pain and short-term memory impairment).

A recent study conducted by researchers at Sun Yat-Sen University in China explores the relationship between neuropathic pain and short-term memory impairment. The study found that deactivation of dorsal CA1 pyramidal neurons projecting to the medial prefrontal cortex contributes to these symptoms. The researchers observed a reduction in excitability and impaired synaptic transmission in these neurons after peripheral nerve injury. Activating the neural circuit from the dorsal hippocampus CA1 to the medial prefrontal cortex alleviated pain behaviors and improved memory in mice, while deactivating this pathway caused pain hypersensitivity and memory deficits. This research provides valuable insights into the complex nature of neuropathic pain and its impact on cognitive function. [Extracted from the article]