State University of Maringa Reports Findings in Central Nervous System Agents (Adult and pediatric physiologically-based biopharmaceutics modeling to explain lamotrigine immediate release absorption process).

A recent study conducted by researchers at the State University of Maringa in Brazil explored the use of physiologically-based biopharmaceutics modeling (PBBM) to understand the absorption process of lamotrigine, a drug commonly prescribed for various conditions. The study focused on the impact of gastrointestinal tract (GIT) physiological parameters on the biopharmaceutics risk of lamotrigine in both adults and children. The researchers developed and verified an oral physiologically-based pharmacokinetic (PBPK) model using GastroPlus(TM) software. The study found that gastric transit time was the most influential parameter and suggested that lamotrigine may exhibit characteristics of a BCS II classification in vitro while showing BCS I-like behavior in vivo. The findings have implications for model-informed precision dosing (MIPD) and assessing the influence of release profiles on the drug's performance in different populations. [Extracted from the article]