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The association of osteoprotegerin and RANKL with osteoporosis: a systematic review with meta-analysis.
- Source :
- Journal of Orthopaedic Surgery & Research; 11/7/2023, Vol. 18 Issue 1, p1-7, 7p
- Publication Year :
- 2023
-
Abstract
- Objectives: The OPG/RANKL signal pathway was important regulation mechanism of bone remodeling cycle, but the effect of osteoprotegerin (OPG) and RANKL in osteoporosis was uncertain. We did a systematic review with meta-analysis to assess the association between serum OPG/RANKL and osteoporosis. Methods: The systematic search, data extraction, critical appraisal, and meta-analysis were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Randomized controlled studies were searched in PubMed, OvidMedline, Embase (1946 to present). Standard mean difference (SMD), and associated credible interval (CI) were calculated using RevMan statistical software to assess the continuous data. Heterogeneity in studies was measured by I<superscript>2</superscript> values. Subgroup analysis was performed based on different bone turnover. Results: A total of 5 randomized controlled studies met the inclusion criteria. Both OPG and RANKL had no significant differences between the osteoporosis and control group, and the statistical heterogeneity was high in meta-analysis. However, RANKL had significant differences between the osteoporosis group with low bone turnover and control group (SMD = − 1.17; 95% CI − 1.77 to 0.57; P value < 0.01) in subanalysis. Furthermore, the OPG/RANKL ratio was significant lower in the osteoporosis group than in the control group (SMD = − 0.29; 95% CI − 0.57 to − 0.02; P value < 0.05), and the statistical heterogeneity was very low (Chi<superscript>2</superscript> = 0.20, P = 0.66, I<superscript>2</superscript> = 0%). Conclusions: Our meta-analysis study supported OPG and RANKL were important modulatory factors of bone formation and resorption in bone turnover, respectively. Although the serum level of both OPG and RANKL were not associated with osteoporosis, but the OPG/RANKL ratio was associated with osteoporosis. In future, standardizing the test method and unit was good to clinical application. [ABSTRACT FROM AUTHOR]
- Subjects :
- BIOMARKERS
ONLINE information services
META-analysis
MEDICAL information storage & retrieval systems
CONFIDENCE intervals
SYSTEMATIC reviews
CELL receptors
OSTEOPOROSIS
COMPARATIVE studies
RESEARCH funding
DESCRIPTIVE statistics
QUALITY assurance
CHI-squared test
MEMBRANE proteins
MEDLINE
DATA analysis software
BLOOD
Subjects
Details
- Language :
- English
- ISSN :
- 1749799X
- Volume :
- 18
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Orthopaedic Surgery & Research
- Publication Type :
- Academic Journal
- Accession number :
- 173456862
- Full Text :
- https://doi.org/10.1186/s13018-023-04179-5